Can plants serve as a vector for prions causing chronic wasting disease?
نویسندگان
چکیده
منابع مشابه
Prions in skeletal muscles of deer with chronic wasting disease.
The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic potential of CWD. Because meat consumption is the most likely means of exposure, it is important to determine whethe...
متن کاملChronic Wasting Disease Prions in Elk Antler Velvet
Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in the apical skin layer covering the growing antler (antler velvet) by using CWD-susceptible transgenic mice and protein misfolding cyclic amplificatio...
متن کاملEnzymatic digestion of chronic wasting disease prions bound to soil.
Chronic wasting disease (CWD) and sheep scrapie can be transmitted via indirect environmental routes, and it is known that soil can serve as a reservoir of prion infectivity. Given the strong interaction between the prion protein (PrP) and soil, we hypothesized that binding to soil enhances prion resistance to enzymatic digestion, thereby facilitating prion longevity in the environment and prov...
متن کاملEnzymatic Digestion of Chronic Wasting Disease Prions Bound to Soil
S A M U E L E . S A U N D E R S , † J A S O N C . B A R T Z , ‡ K U R T C . V E R C A U T E R E N , § A N D S H A N N O N L . B A R T E L T H U N T * , † Department of Civil Engineering, Peter Kiewit Institute, University of NebraskasLincoln, Omaha, Nebraska 68588, Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska 68178, and USDA Animal and Plant Health In...
متن کاملChronic wasting disease: Emerging prions and their potential risk
Prions cause fatal neurodegenerative diseases in humans and animals by converting the cellular prion protein PrP into aggregation-prone PrP. Chronic wasting disease (CWD) is a prion disease or transmissible spongiform encephalopathy (TSE) of free-ranging and farmed cervids. CWD is highly contagious and transmitted through horizontal transmission enabled by the shedding of prions in excreta and ...
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ژورنال
عنوان ژورنال: Prion
سال: 2014
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.27963